Acute muscular weakness in children

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Acute muscular weakness in children.

Acute muscle weakness in children is a pediatric emergency. During the diagnostic approach, it is crucial to obtain a detailed case history, including: onset of weakness, history of associated febrile states, ingestion of toxic substances/toxins, immunizations, and family history. Neurological examination must be meticulous as well. In this review, we describe the most common diseases related t...

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Mechanisms of muscle weakness in muscular dystrophy

Disruption of dystrophin or the sarcoglycans within the dystrophin protein complex leads to muscular dystro-phy. The dystrophin complex is enriched in myofibers and concentrated into costameres, rib-like structures in the plasma membrane. In the absence of dystrophin, the plasma membrane becomes fragile with reduced stiffness and increased leakiness, and exposing dystro-phin-deficient muscle to...

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Quantitative electromyographic changes assocsiated with muscular weakness.

It has been shown that when a human muscle contracts the mean voltage of the electromyogram recorded from its surface increases with the force of the contraction (Bayer and Flechtenmacher, 1950; Inman, Ralston, Saunders, Feinstein, and Wright, 1952; Lippold, 1952). The relationship between tension and mean voltage is linear provided the contraction is isometric (Lippold, 1952). With an isotonic...

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Acute and subacute weakness.

Respiratory failure is a common complication of acute neuromuscular disease and high cervical cord lesions and should be monitored by measuring forced vital capacity and respiratory rate. Urgent imaging is mandatory if there is any clinical suspicion of spinal cord disease. Treatment of Guillain-Barré syndrome with plasma exchange or intravenous immunoglobulin (IVIg) speeds up the rate of recov...

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Elderly Onset of Weakness in Facioscapulohumeral Muscular Dystrophy

A 77-year-old male is presented. He had onset of proximal weakness 10 years earlier. His course was slowly progressive. Despite having phenotypic features of facioscapulohumeral muscular dystrophy (FSH), genetic testing for this was delayed because of his age of onset, lack of family history, and benign appearing muscle biopsy. This case is one of the oldest onset of weakness in genetically con...

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ژورنال

عنوان ژورنال: Arquivos de Neuro-Psiquiatria

سال: 2017

ISSN: 0004-282X

DOI: 10.1590/0004-282x20170026